Optimising Health by System: Evidence-Based Compounds for Brain, Heart, Muscle, Liver, and Sleep
Matt Lovell 2 min read

Optimising Health by System: Evidence-Based Compounds for Brain, Heart, Muscle, Liver, and Sleep

Healthy ageing starts with the fundamentals: a nutrient-rich Mediterranean-style diet, quality protein, regular movement, deep sleep, and effective stress management. Once these foundations are in place, you can target specific systems with proven nutrients and supplements to support resilience, longevity, and vitality.

This guide maps five key systems – Brain, Heart, Muscle, Liver, and Sleep – with evidence-backed compounds, plus how Amino Man products align for practical, real-world use.

1. Brain – Cognition, Neuroprotection, Inflammation Control

  • Omega-3 (DHA/EPA): Supports brain membranes, reduces neuroinflammation

  • NMN or NR: Boosts NAD⁺ for energy and DNA repair

  • Spermidine: Encourages protein clearance and cell renewal

  • CoQ10: Mitochondrial energy and antioxidant support

  • L-Theanine: Promotes calm focus

Match: Focus Sustain – for neurotransmitter balance and brain stamina.

2. Heart – Endothelial Health, Anti-Inflammation, Energy

  • Omega-3: Heart rhythm and vessel support

  • CoQ10: Restores mitochondrial efficiency

  • Spermidine: Cardiac autophagy and elasticity

  • NMN or NR: Enhances vascular NAD⁺ levels

  • Curcumin: Potent anti-inflammatory

Match: Metabolic Optimiser – supports vascular health and recovery.

3. Muscle & Recovery – Strength, Repair, Mitochondrial Capacity

  • Creatine: Energy for muscle strength and performance

  • Protein/EAAs: Prevents muscle loss and supports recovery

  • Omega-3: Reduces soreness and joint pain

  • NMN or NR: Boosts endurance and mitochondria

  • Spermidine: Improves metabolic efficiency

Match: Amino Loader – creatine and amino synergy for strength and recovery.

4. Liver & Detox – Protection, Renewal, Antioxidant Support

  • Spermidine: Autophagy and anti-fibrosis

  • Curcumin: Liver protection

  • Milk Thistle: Hepatic cell support

  • CoQ10: Detox energy

  • NMN or NR: NAD⁺ for phase I/II detox

Match: Metabolic Optimiser – curcumin and milk thistle blend.

5. Sleep & Hormones – Circadian Rhythm, Stress, Male Health

  • Magnesium: Calm and melatonin synthesis

  • Melatonin: Sleep cycle regulation

  • Ashwagandha: Stress adaptation

  • Spermidine: Overnight repair

  • C15:0: Emerging metabolic resilience

Match: R5 Aminos, Adrenal T-Max, Fish Oils – for hormonal health and recovery.

Spermidine Dosing:
Research supports 1–2 mg/day for cognition; 3–4 mg/day for heart, hormones, and metabolic health; 4–6 mg/day for liver and muscle support. Always check supplement labels for pure content.