AquaCelle®️ CoQ10 Ubiquinone (100mg) Supplement

• Energy Metabolism Support – Contributes to normal energy-yielding metabolism by assisting the body in converting nutrients into usable energy throughout the day.
• Cellular Health Maintenance – Helps maintain normal cell function by supporting the body’s natural antioxidant processes.
• Cardiovascular Support – Supports healthy heart and vascular function as part of a balanced wellbeing routine.
• Fatigue Reduction – Contributes to the normal reduction of tiredness and fatigue, helping you feel supported during daily activities.
• Muscle Function Maintenance – Helps maintain normal muscle function by supporting healthy cellular energy pathways.
• Oxidative Stress Protection – Contributes to normal protection of cells from oxidative stress, promoting everyday wellbeing.
• Absorption Support – Supports normal nutrient absorption with a delivery system designed to optimise uptake.

Take 2 softgels daily with food, or as directed. Up to 2 servings per day may be used. Store in a cool, dry place. Keep out of reach of children.

Coenzyme Q10

Other Ingredients:Soybean Oil, Beeswax, Sunflower Lecithin, Tocopherol-rich Extract.

Serving Size: 2 softgels • Servings per Container: 60 (120 softgels)

Per Softgel:

• Aquacelle® Coenzyme Q10 (Ubiquinone) – 50mg
  

Per Serving (2 softgels):

• Aquacelle® Coenzyme Q10 (Ubiquinone) – 100mg
  

Other Ingredients:

Soybean Oil, Beeswax, Sunflower Lecithin, Tocopherol-rich Extract.

Allergens: None

AquaCelle® CoQ10 uses a self-microemulsifying drug delivery system (SMEDDS) to overcome the poor water solubility of standard CoQ10 ubiquinone, significantly enhancing absorption and bioavailability. The following summarises the key research supporting CoQ10 and the AquaCelle® delivery technology.

1. AquaCelle® Enhanced Absorption Technology

Standard CoQ10 ubiquinone has inherently poor bioavailability due to its large molecular size and lipophilic nature. AquaCelle® uses a self-microemulsifying system that spontaneously forms nano-sized droplets in the gastrointestinal tract, dramatically increasing the surface area available for absorption. Studies on SMEDDS-based CoQ10 formulations demonstrate significantly higher plasma CoQ10 levels compared to conventional powder or oil-based capsules.

Reference: Balakrishnan P et al. International Journal of Pharmaceutics (2009). Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery.

2. Cellular Energy Production

CoQ10 is an indispensable component of the mitochondrial electron transport chain, facilitating the transfer of electrons between complexes I, II, and III to drive ATP synthesis. Every cell in the body depends on this process for energy, with the heart, brain, liver, and skeletal muscle having the greatest CoQ10 requirements. Natural CoQ10 levels decline significantly with age, making supplementation increasingly relevant from the fourth decade onwards.

Reference: Littarru GP, Tiano L. Molecular Biotechnology (2007). Bioenergetic and antioxidant properties of coenzyme Q10: recent developments.

3. Cardiovascular Support

CoQ10 is highly concentrated in cardiac tissue and plays a critical role in maintaining myocardial energy supply. The Q-SYMBIO trial — a multicentre, randomised, double-blind, placebo-controlled study — demonstrated that CoQ10 supplementation (300 mg/day) significantly reduced major adverse cardiovascular events and cardiovascular mortality in patients with chronic heart failure over a 2-year period.

Reference: Mortensen SA et al. JACC: Heart Failure (2014). The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO.

4. Antioxidant Defence

CoQ10 functions as a lipid-soluble antioxidant, protecting mitochondrial membranes and circulating lipoproteins from oxidative damage. It also regenerates other antioxidants including vitamin E. Clinical studies confirm that CoQ10 supplementation reduces circulating markers of oxidative stress and lipid peroxidation, which are associated with ageing and chronic disease risk.

Reference: Ernster L, Dallner G. Biochimica et Biophysica Acta (1995). Biochemical, physiological and medical aspects of ubiquinone function.

5. Statin-Induced CoQ10 Depletion

Statins inhibit the mevalonate pathway, which is responsible for both cholesterol and CoQ10 synthesis. This results in measurable reductions in plasma and muscle CoQ10 levels, which may contribute to statin-associated myopathy. Multiple studies have shown that CoQ10 supplementation can restore depleted levels and may help reduce muscle-related side effects in statin users.

Reference: Marcoff L, Thompson PD. Journal of the American College of Cardiology (2007). The role of coenzyme Q10 in statin-associated myopathy: a systematic review.