Welcome to Your Cellular Rejuvenation Reset

 

At the heart of this approach is a simple but powerful concept: senescence. When cells stop dividing but refuse to die, they become “zombie” cells - releasing inflammatory molecules that accelerate aging and disease.  Clearing these cells can reduce inflammation, improve tissue repair, and restore youthful cellular function.

 

By combining senolytic and autophagy-activating compounds with strategic caloric modulation, this short protocol helps reset your system, reduce inflammation, and reignite mitochondrial function for lasting vitality.
 
Natural  Senolytics & Senomorphics
 
While pharmaceutical senolytics are still being studied, a number of natural compounds found in everyday foods have been shown to either clear senescent cells (senolytics) or suppress their harmful effects (senomorphics).

 

The table below highlights some of the best-researched options, their food sources, mechanisms of action, and complementary synergies for supporting cellular rejuvenation.

Supportive Compounds

Alongside the natural senolytics above, several other nutrients can help enhance cellular rejuvenation, balance inflammation, and support detoxification.

Key allies: Berberine, Green Tea Extract, NMN, Resveratrol, Olive Leaf Extract, Rutin, Broccoli Extract (sulforaphane), Omega-3 fatty acids, and Milk Thistle (for liver support).

Product note: Metabolic Optimiser (270 tablets per pack) includes Quercetin, Green Tea Extract, Berberine, Milk Thistle, Ginger, Curcumin, Boswellia, and other antioxidant compounds — a solid foundation for this reset.

Calorie Strategy

For this 5-day protocol, we’re aiming to mimic the benefits of fasting while maintaining stable energy and supporting recovery.

Daily calorie target: 75% of your body weight (kg) = target calories
Example: 100 kg = ~750 kcal/day

Macronutrient focus: High protein (~60–70 g), moderate complex carbs, minimal fats

This approach mirrors the ProLon-style fasting-mimicking diet, which research shows can enhance longevity markers, activate autophagy, and stimulate stem-cell renewal (Longo et al., Cell Metabolism, 2015). You can order Prolon via their website if you want to use that system: https://prolon.co.uk

You can also read my experience of their plan here: https://medium.com/@matt-lovell/my-experience-of-the-prolon-fasting-mimicking-diet-2e7f3c062ceb 

 If you’ve not got time, it’s pretty good but you can do it yourself also.

Daily Rhythm

Morning:

Hydrate: 500 ml water + electrolytes + black coffee or green tea
Aminos: 1 scoop Metabolic Amino Complex + 1 tsp psyllium husk for satiety

Supplements:

• 9 × Metabolic Optimiser
• 3 × NMN
• 2 × Spermidine
• 12 × Fisetin + Quercetin or 1 × Liposomal Apigenin 600 mg

Pre-training stack (optional): Adrenal T Max × 5 caps + Tongkat Ali (600 mg), Fadogia Agrestis (400 mg), Horny Goat Weed (2 tabs)

Light training, yoga, walking or sauna stretching all complement this phase beautifully — helping fat mobilisation and growth hormone release.

Midday:

Bone Broth (250 ml): Collagen, glycine, minerals
Optional: Matcha or herbal tea

Evening Meal (500–750 kcal)
Focus on protein-dense, high-polyphenol, low-glycaemic foods.

• Salmon & Broccoli Bowl: Wild salmon, steamed broccoli, cauliflower rice, olive oil, lemon, herbs
• Vegan Detox Soup: Lentils, spinach, turmeric, garlic, bone broth or vegetable base
• Chicken & Berry Salad: Chicken breast, greens, blueberries, walnuts, apple-cider vinegar
• Egg & Veg Scramble: Eggs, mushrooms, kale, avocado
• Protein Dessert: Cottage cheese or coconut yogurt + raspberries + cinnamon

After dinner, light movement (a walk or gentle stretch) supports digestion and recovery. Try R5’s Amino or Amber Amino Adaptogenic Hot Chocolate post-evening movement to aid sleep and repair.

Evening Supplements

• Multivitamin + minerals (4–6 caps)
• Olive Leaf Extract (1000 mg)
• Rutin (1000 mg)
• Broccoli Extract (10 tabs)
• Liposomal Apigenin (600 mg)
• Omega-3s (2–4 g EPA/DHA)
• Milk Thistle (1000 mg AM + PM)
• Berberine (500–1000 mg)

• Sauna Therapy: 20 mins at 70–80 °C for heat-shock proteins and detoxification
• Massage or Contrast Showers: Boost circulation and recovery
• Sleep: Prioritise early nights; magnesium glycinate supports sleep onset
• Hydration: 2.5–3 L water/day + electrolytes

Tracking & Re-Feed

Before and after your 5-day reset, measure: weight, waist circumference, body-fat %, HRV, and fasting glucose.

Day 6: Reintroduce nutrient-dense foods (e.g. eggs, avocado, quinoa, berries).

Continue key senolytics like Quercetin 500 mg + Fisetin 500 mg 2–3 days per week to maintain benefits.

Repeat the 5-day reset monthly or quarterly for best results.

Safety & Contraindications

• Avoid during acute illness or pregnancy.
• Be cautious if using anticoagulants or metformin (seek guidance first).
• Stay on top of electrolytes to prevent fatigue.
• If dizziness occurs, increase protein and fluids.

Tips from the Top

Sauna stretching is excellent — just keep hydrated.
Massage daily if possible; it supports detox and distracts from hunger.
Doing this with a friend helps accountability.

Don’t stress if you go slightly over on calories — just extend the plan by a day.
Record your baseline metrics before Day 1, and retake them on the morning of Day 6.

If you want support I can help you plan, tailor the supplements, and walk you through each day of the reset. Please just email me at matt@aminoman.com