- Support cellular renewal through senolytic and autophagy-activating compounds
- Achieve a metabolic reset via gentle caloric restriction and fasting physiology
- Reduce inflammation and oxidative stress
- Encourage fat loss and boost mitochondrial efficiency
Natural Senolytics & Senomorphics
While pharmaceutical senolytics are still being studied, a number of natural compounds found in everyday foods have been shown to either clear senescent cells (senolytics) or suppress their harmful effects (senomorphics).

Supportive Compounds
Alongside the natural senolytics above, several other nutrients can help enhance cellular rejuvenation, balance inflammation, and support detoxification.
Key allies: Berberine, Green Tea Extract, NMN, Resveratrol, Olive Leaf Extract, Rutin, Broccoli Extract (sulforaphane), Omega-3 fatty acids, and Milk Thistle (for liver support).
Product note: Metabolic Optimiser (270 tablets per pack) includes Quercetin, Green Tea Extract, Berberine, Milk Thistle, Ginger, Curcumin, Boswellia, and other antioxidant compounds — a solid foundation for this reset.
Calorie Strategy
For this 5-day protocol, we’re aiming to mimic the benefits of fasting while maintaining stable energy and supporting recovery.
Daily calorie target: 75% of your body weight (kg) = target calories
Example: 100 kg = ~750 kcal/day
Macronutrient focus: High protein (~60–70 g), moderate complex carbs, minimal fats
- Morning: Aminos + hydration + adaptogens
- Midday: Bone broth + electrolytes + light movement
- Evening: Main meal (~500–750 kcal)
This approach mirrors the ProLon-style fasting-mimicking diet, which research shows can enhance longevity markers, activate autophagy, and stimulate stem-cell renewal (Longo et al., Cell Metabolism, 2015). You can order Prolon via their website if you want to use that system: https://prolon.co.uk
You can also read my experience of their plan here: https://medium.com/@matt-lovell/my-experience-of-the-prolon-fasting-mimicking-diet-2e7f3c062ceb
If you’ve not got time, it’s pretty good but you can do it yourself also.
Daily Rhythm
Morning:
Hydrate: 500 ml water + electrolytes + black coffee or green tea
Aminos: 1 scoop Metabolic Amino Complex + 1 tsp psyllium husk for satiety
Supplements:
- 9 × Metabolic Optimiser
- 3 × NMN
- 2 × Spermidine
- 12 × Fisetin + Quercetin or 1 × Liposomal Apigenin 600 mg
Pre-training stack (optional): Adrenal T Max × 5 caps + Tongkat Ali (600 mg), Fadogia Agrestis (400 mg), Horny Goat Weed (2 tabs)
Light training, yoga, walking or sauna stretching all complement this phase beautifully — helping fat mobilisation and growth hormone release.
Midday:
Bone Broth (250 ml): Collagen, glycine, minerals
Optional: Matcha or herbal tea
Evening Meal (500–750 kcal)
Focus on protein-dense, high-polyphenol, low-glycaemic foods.
- Salmon & Broccoli Bowl: Wild salmon, steamed broccoli, cauliflower rice, olive oil, lemon, herbs
- Vegan Detox Soup: Lentils, spinach, turmeric, garlic, bone broth or vegetable base
- Chicken & Berry Salad: Chicken breast, greens, blueberries, walnuts, apple-cider vinegar
- Egg & Veg Scramble: Eggs, mushrooms, kale, avocado
- Protein Dessert: Cottage cheese or coconut yogurt + raspberries + cinnamon
After dinner, light movement (a walk or gentle stretch) supports digestion and recovery. Try R5’s Amino or Amber Amino Adaptogenic Hot Chocolate post-evening movement to aid sleep and repair.
Evening Supplements
- Multivitamin + minerals (4–6 caps)
- Olive Leaf Extract (1000 mg)
- Rutin (1000 mg)
- Broccoli Extract (10 tabs)
- Liposomal Apigenin (600 mg)
- Omega-3s (2–4 g EPA/DHA)
- Milk Thistle (1000 mg AM + PM)
- Berberine (500–1000 mg)
- Sauna Therapy: 20 mins at 70–80 °C for heat-shock proteins and detoxification
- Massage or Contrast Showers: Boost circulation and recovery
- Sleep: Prioritise early nights; magnesium glycinate supports sleep onset
- Hydration: 2.5–3 L water/day + electrolytes
Tracking & Re-Feed
Before and after your 5-day reset, measure: weight, waist circumference, body-fat %, HRV, and fasting glucose.
Day 6: Reintroduce nutrient-dense foods (e.g. eggs, avocado, quinoa, berries).
Continue key senolytics like Quercetin 500 mg + Fisetin 500 mg 2–3 days per week to maintain benefits.
Repeat the 5-day reset monthly or quarterly for best results.
Safety & Contraindications
- Avoid during acute illness or pregnancy.
- Be cautious if using anticoagulants or metformin (seek guidance first).
- Stay on top of electrolytes to prevent fatigue.
- If dizziness occurs, increase protein and fluids.
Tips from the Top
Sauna stretching is excellent — just keep hydrated.
Massage daily if possible; it supports detox and distracts from hunger.
Doing this with a friend helps accountability.
Don’t stress if you go slightly over on calories — just extend the plan by a day.
Record your baseline metrics before Day 1, and retake them on the morning of Day 6.
If you want support I can help you plan, tailor the supplements, and walk you through each day of the reset. Please just email me at matt@aminoman.com